Publications

Colorful illustration

Scientific Papers

Mediouni S, Mou H, Otsuka Y, Jablonski JA, Adcock RS, Batra L, Chung D, Rood C, S. de Vera IA, Rahaim R, Ullah S, Yu X, Nguyen T, Hull M, Chen E, Bannister TD, Scampavia L, Farzan M*, Valente ST*, Spicer TP*. Identification of Potent Small Molecules Inhibitors of SARS-CoV-2 Entry. *Equal contribution. 2022. SLAS Discovery. 2022 Jan;27(1):8-19. doi: 10.1016/j.slasd.2021.10.012. Epub 2021 Oct 23

Wang H, Yuan Z, Pavel MA, Mediouni-Jablonski S, Jablonski JA, Hobson R, Valente ST, Reddy, CB, Hansen SB. The role of high cholesterol in age-related COVID19 lethality.2020 bioRxiv. 2020 May, preprint PubMed PMID: 32511366. PubMed Central PMCID: PMC7263494. https://doi.org/10.1101/2020.05.09.086249

Deeks SG, Lewin SR, Valente ST, et al. International AIDS Society global scientific strategy: towards an HIV cure 2021. Nat Med. 2021 Dec;27(12):2085-2098. doi: 10.1038/s41591-021-01590-5. Epub 2021 Dec 1.

Premeaux TA, Mediouni S, Leda A, Furler RL, Valente ST, Fine HA, Nixon DF, and Ndhlovu LCNext Generation Human Cerebral Organoids as Powerful tools to Advance NeuroHIV Research. 2021. mBio. PubMed PMID: 34253056. DOI:10.1128/mBio.00680-21. https://doi.org/10.1128/mBio.00680-21 

Swarnkar S, Avchalumov Y, Espadas I, Grinman E, Liu X, Raveendra BL, Zuca A, Mediouni S, Valente STPage D, Miller K, Puthanveettil SV. The Molecular Motor Protein KIF5C Mediates Structural Plasticity and Long-Term Memory by Constraining Local Translation. 2021. Cell Reports. 2021 July 13, vol36, Issue 2. PedMed PMID: 34260917. PubMed Central PMCID: PMC8319835. doi: 10.1016/j.celrep.2021.109369. https://doi.org/10.1016/j.celrep.2021.109369

Li C, Mori L and Valente ST. The block-and-lock strategy for Human Immunodeficiency Virus Cure: Lessons Learned from didehydro-Cortistatin A. Journal of Infectious Diseases. 2021 Feb15; 223:46-53. PubMed PMID: 33586776.  PubMed Central PMCID: PMC7883021. DOI:10.1093/infdis/jiaa681. https://doi.org/10.1093/infdis/jiaa681

Moranguinho I and Valente ST. Block-and-Lock: new horizons for a cure for HIV. Viruses. 2020 Dec15.12(2):1443. PubmEd PMID: 33334019. PubMed Central PMCID: PMC7765451. doi: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765451/

Mori L, Jenike K, Yeh YJ, Lacombe B, Li C, Getzler A, Mediouni S, Cameron M, Pipkin M, Ho YC, Ramirez BC, Valente S. The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency. Journal of Virology. 2020 Nov 25;. doi: 10.1128/JVI.01247-20. PubMed PMID: 33239456; PubMed Central PMCID: PMC7851559. doihttps://doi.org/10.1128/JVI.01247-20

Vartak R, Patki M, Menon S, Jablonski J, Mediouni S, Fu Y, Valente ST, Billack B, Patel K. β-cyclodextrin polymer/Soluplus® encapsulated Ebselen ternary complex (EβpolySol) as a potential therapy for vaginal candidiasis and pre-exposure prophylactic for HIV. Int J Pharm. 2020 Nov 15;589:119863. doi: 10.1016/j.ijpharm.2020.119863. Epub 2020 Sep 8. PubMed PMID: 32911046. doi: https://doi.org/10.1016/j.ijpharm.2020.119863

Patki M, Vartak R, Jablonski J, Mediouni S, Gandhi T, Fu Y, Cetindag E, Dave R, Valente ST, Patel K. Efavirenz Nanomicelles Loaded Vaginal Film (EZ film) for Preexposure Prophylaxis (PrEP) of HIV. 2020. Colloids and Surfaces B: Biointerfaces. 2020 Oct; 194:111174. DOI:10.1016/j.colsurfb.2020.111174. PubMed: PMID: 32540766. https://doi.org/10.1016/j.colsurfb.2020.111174

Mediouni S, Jablonski JA, Tsuda S, Barsamian A, Kessing C, Richard A, Biswas A, Toledo F, Andrade VM, Even Y, Stevenson M, Tellinghuisen T, Choe H, Cameron M, Bannister TD, Valente ST. Oregano Oil and Its Principal Component, Carvacrol, Inhibit HIV-1 Fusion into Target Cells. Journal of Virology. 2020 Jul 16;94(15). doi: 10.1128/JVI.00147-20. Print 2020 Jul 16. PubMed PMID: 32461309; PubMed Central PMCID: PMC7375364. doihttps://doi.org/10.1128/JVI.00147-20

Mori L and Valente S. Key Players in HIV-1 Transcriptional Regulation: Targets for a Functional Cure. Viruses. 2020, 12(5), 529; doi:10.3390/v12050529. PubMed PMID: 32403278. PubMed Central: PMC7291152. doi: https://doi.org/10.3390/v12050529

Mousseau G, Aneja R, Clementz MA, Kessing CF, Jablonski J, Thenin-Houssier S, Mediouni S, Nagarsheth N, Valente ST. Resistance to the Tat inhibitor didehydro-Cortistatin A is mediated by heightened basal HIV-1 transcription.  2019. mBio. 2019 Jul 2;10(4):e01750-18. DOI: 10.1128/mBio.01750-18. PubMed PMID: 31266880. PubMed Central PMCID: PMC6606815. 
doihttps://doi.org/10.1128/mBio.01750-18

Mediouni S, Kessing C, Thenin-Houssier S, Clementz M, Mousseau G, de Vera IM, Kovak MD, Jablonski J, Kojetin DJ, Evans D & Valente ST. The Tat inhibitor didehydro-Cortistatin A suppresses SIV replication and reactivation. FASEB Journal. 2019 Jul;33(7):8280-8293. PubMed PMID: 31021670. PubMed Central PMCID: PMC6593873.  doi: https://doi.org/10.1096/fj.201801165R

Takata H, Kessing C, Sy A, Sciumbata J, Lima N, Mori L, Jones BR, Chomont N, Miachael NL, Valente ST and Trautmann L. Modeling HIV-1 latency using primary CD4+T cells from Virally Suppressed HIV-1 infected Individuals on Antiretroviral Therapy. Journal of Virology. 2019 March 15:93(11):e02248-18. PubMed PMID: 30918073. PubMed Central PMCID: PMC6532074. DOI: 10.1128/JVI.02248-18. doi:  https://doi.org/10.1128/JVI.02248-18

Li C, Mousseau G, Valente ST. Tat inhibition by didehydro-Cortistatin A promotes heterochromatin formation at the HIV-1 Long Terminal repeat. Epigenetics & Chromatin. 2019 April 16;12(1):23. doi: 10.1186/s13072-019-0267-8.PubMed PMID: 30992052. PubMed Central PMCID: PMC6466689. https://doi.org/10.1186/s13072-019-0267-8

Mediouni S, Chinthalapudi K, Ekka M, Usui I, Jablonski J, Clementz M, Mousseau G, Nowak J, Macherla VR, Beverage JN, Esquenazi E, Baran P, Loret EP, Nettles K, Maiti S, Izard T, Valente ST. Didehydro-Cortistatin A inhibits the activity of HIV-1 by specifically binding to the unstructured basic region of Tat. mBio. 2019 Feb 5;10(1). pii: e02662-18. doi: 10.1128/mBio.02662-18. PubMed PMDI: 30723126. PubMed Central PMCID: PMC6368365. doihttps://doi.org/10.1128/mBio.02662-18

Mediouni S, Jablonski JA, Tsuda S, Richard A, Kessing CF, Andrade MV, Biswas A, Even Y, Tellinghuisen T, Choe H, Cameron M, Stevenson M, Valente ST. Potent suppression of HIV-1 cell attachment by Kudzu root extract. Retrovirology. 2018; Sep 20:15(1):64.doi: 10.1186/s12977-018-0446-x. PubMed PMID: 30236131. PubMed Central PMCID: PMC6149077. https://retrovirology.biomedcentral.com/articles/10.1186/s12977-018-0446-x

Kessing CF, Nixon CC, Li C, Tsai PM, Takata H, Mousseau G, Ho PT, Honeycutt JB, Fallahi M, Trautmann L, Garcia JV, Valente ST. In vivo suppression of HIV rebound by didehydro-Cortistatin A, a novel “block-and-lock” strategy for HIV-1 Treatment. Cell Reports. 2017; 21(3):600-611. PubMed PMID: 29045830; NIHMSID: NIHMS910101; PubMed Central PMCID: PMC5653276. doi: https://doi.org/10.1016/j.celrep.2017.09.080

Mousseau G. & Valente ST. Role of Host Factors on the Regulation of Tat-Mediated HIV-1 Transcription. Current Pharmaceutical Design. 2017; 23(28):4079-4090. PubMed PMID: 28641539; NIHMSID: NIHMS924849; PubMed Central PMCID: PMC5731639. doi : 10.2174/1381612823666170622104. https://www.ncbi.nlm.nih.gov/pubmed/28641539

Wu H, Mousseau G, Mediouni S, Valente ST, Kodadek T. Cell-permeable peptides containing cycloalanine Residues. Angewandte Chem In Ed Engl. 2016;55(41):12637-42. PubMed PMID: 27529332; NIHMSID: NIHMS833797; PubMed Central PMCID: PMC5220248. doi: https://doi.org/10.1002/anie.201605745

Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F; International AIDS Society Towards a Cure Working Group, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016: 22(8):839-50. PubMed PMID: 27400264; NIHMSID: NIHMS848236; PubMed Central PMCID: PMC5322797. https://doi.org/10.1038/nm.4108

Thenin-Houssier S, de Vera IM, Pedro-Rosa L, Brady A, Richard A, Konnick B, Opp S, Buffone C, Fuhrmann J, Kota S, Billack B, Pietka-Ottlik M, Tellinghuisen T, Choe H, Spicer T, Scampavia L, Diaz-Griffero F, Kojetin DJ & Valente ST. Ebselen, a small molecule capsid-inhibitor of HIV-1 replication. Antimicrob Agents Chemother. 2016; 60(4):2195-208. PubMed PMID: 26810656; PubMed Central PMCID: PMC4808204. https://doi.org/10.1128/AAC.02574-15

Mousseau G & Valente ST. Didehydro-Cortistatin A: A new player in HIV-therapy? Expert Rev Anti Infect Ther. 2016;14(2):145-8. PubMed PMID: 26581953; NIHMSID: NIHMS764000; PubMed Central PMCID: PMC4793404. doi: 10.1586/14787210.2016.1122525. https://doi.org/10.1586/14787210.2016.1122525

Thenin-Houssier S & Valente ST. HIV-1 capsid inhibitors as antiretroviral agents. Current HIV Research. 2016; 14(3):270-82. PubMed PMID: 26957201; NIHMSID: NIHMS740513; PubMed Central PMCID: PMC4785820. doi: 10.2174/1570162×14999160224103555. https://www.ncbi.nlm.nih.gov/pubmed/26957201

Mediouni S, Marcondes MCG, Miller C, McLaughlin JP, Valente ST. The cross-Talk of HIV-1 Tat and Methamphetamine in HIV associated neurocognitive disorders. Front. Microbiol. 2015; 6:1164. PubMed PMID: 26557111; PubMed Central PMCID: PMC4615951. doi: https://doi.org/10.3389/fmicb.2015.01164

Mousseau G., Kessing, C., Fromentin R., Trautmann, L., Chomont N. and Valente ST. The Tat inhibitor didehydro-Cortistatin A prevents HIV-1 reactivation from latency. mBio. 2015; 6 (4):e00465. PubMed PMID: 26152583; PubMed Central PMCID: PMC4495168. Editors’ Pick. doi: https://doi.org/10.1128/mbio.00465-15

Mediouni S, Paris JJ, Jablonski J, Clementz M, Thenin-Houssier S, McLaughlin JP, Valente ST. Didehydro-Cortistatin A inhibits HIV-1 Tat mediated Neuroinflammation and Prevents Potentiation of Cocaine Reward in Tat Transgenic Mice. Current HIV Research. 2015; 13(1):64-79. PubMed PMID: 25613133; NIHMSID: NIHMS679919; PubMed Central PMCID: PMC4416414. doi:10.2174/1570162X13666150121111548. https://pubmed.ncbi.nlm.nih.gov/25613133/

Jablonski J, Clementz M, Ryan K, Valente ST. Analysis of RNA processing reactions using cell free systems: 3′ end cleavage of pre-mRNA substrates in vitro. JoVE. 2014; 3(87):51309. PubMed PMID: 24835792; NIHMSID: NIHMS533499; PubMed Central PMCID: PMC4030693. doi: https://doi.org/10.3791/51309

Mousseau G & Valente ST. Strategies to Block HIV Transcription: Focus on Small Molecule Tat Inhibitors. Biology. 2012; 1(3), 668-697. PubMed PMID: 24832514; PubMed Central PMCID: PMC4009808. doi: https://doi.org/10.3390/biology1030668

Mousseau G, Clementz M, Bakeman W, Nagarsheth N, Cameron M, Shi J, Baran P, Fromentin R, Chomont N & Valente ST. An analog of the Natural Steroidal Alkaloid Cortistatin A potently suppresses Tat-dependent HIV transcription. Cell Host & Microbe. 2012; 12(1):97-108. PubMed PMID: 22817991; NIHMSID: NIHMS390360; PubMed Central PMCID: PMC3403716. doi: https://doi.org/10.1016/j.chom.2012.05.016

Valente ST*, Gilmartin GM, Venkataraman K, Arriagada G & Goff SP. HIV-1 mRNA 3’ end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8. Molecular Cell. 2009; 23;36(2):279-89   PubMed PMID: 19854136; NIHMSID: NIHMS156755; PubMed Central PMCID: PMC3068534. *corresponding author. doi: https://doi.org/10.1016/j.molcel.2009.10.004

Valente ST, Gilmartin GM, Mott C, Falkard B & Goff SP. Inhibition of HIV-1 replication by eIF3f. Proc Natl Acad Sci USA. 2009; 106(11):4071-4078. PubMed PMID: 19237569; PubMed Central PMCID: PMC2646627.doi: https://doi.org/10.1073/pnas.0900557106

Naghavi MH, Valente S, Hatziioannou T, de Los Santos K, Wen Y, Mott C, Gundersen GG & Goff SP. Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells. EMBO Journal. 200726:41-52. PubMed PMID: 17170707; PubMed Central PMCID: PMC1782362. doi: https://www.embopress.org/doi/full/10.1038/sj.emboj.7601475

Valente S & Goff SP. Inhibition of HIV-1 Gene Expression by a Fragment of hnRNP U. Molecular Cell. 2006; 23(4):597-605. PubMed PMID: 16916646. doi: https://doi.org/10.1016/j.molcel.2006.07.021

Hazan U, Romero IA, Cancello R, Valente S, Perrin V, Mariot V, Dumonceaux J, Gerhardt CC, Strosberg AD, Couraud PO & Pietri-Rouxel F. Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: a new target cell type for the immunodeficiency virus-1? FASEB Journal. 2002; 16(10):1254-1256. PubMed PMID: 12153994. doi: https://doi.org/10.1096/fj.01-0947fje

Valente ST, Chanel C, Dumonceaux J, Olivier R, Marullo S, Briand P & Hazan U. CXCR4 is down-regulated in cells infected with the CD4-independent X4 human immunodeficiency virus type 1 isolate m7NDK. Journal of Virology. 2001; 75:439-447. PubMed PMID: 11119612; PubMed Central PMCID: PMC113936. doi:  https://doi.org/10.1128/jvi.75.1.439-447.2001

Dumonceaux J, Chanel C, Valente S, Quivet L, Briand P & Hazan U. Mutations in the env gene of human immunodeficiency virus type 1 NDK isolates and the use of African green monkey CXCR4 as a co-receptor in COS-7 cells. Journal of General Virology. 1999; 80 (8):1975-1982. PubMed PMID: 10466793. doi: https://doi.org/10.1099/0022-1317-80-8-1975

Book Chapters

Mori L and Valente ST. Chapter 6. Cure and long-term remission strategies. Methods in Molecular Virology, HIV reservoirs: modeling, quantification, and approached to a cure. 2022. HIV Reservoirs. 2022;2407:391-428. doi: 10.1007/978-1-0716-1871-4_26.

Na M, Valente ST & Ryan K. Optimizing In Vitro Pre-mRNA 3′ Cleavage Efficiency: Reconstitution from Anion-Exchange Separated HeLa Cleavage Factors and from Adherent HeLa Cell Nuclear Extract. Methods Mol Biol. 2017; 1507:179-198. PubMed PMID: 27832541. doi:  https://doi.org/10.1007/978-1-4939-6518-2_14

Mousseau G, Mediouni S & Valente ST. Targeting HIV transcription: The Quest for a Functional Cure. Current Topics in Microbiology and Immunology. Series on novel and future small molecule treatments for HIV; 2015; 389:121-45. PubMed PMID: 25731772; NIHMSID: NIHMS680213; PubMed Central PMCID: PMC4409574.doi:10.1007/82_2015_435. https://pubmed.ncbi.nlm.nih.gov/25731772/

Valente ST & Goff SP. Somatic Cell Genetic Analyses to Identify HIV-1 Host Restriction Factors.Methods Molecular Biology. 2009; 485:235-255. PubMed PMID: 19020830; NIHMSID: NIHMS518013; PubMed Central PMCID: PMC3804074. doi: https://doi.org/10.1007/978-1-59745-170-3_17